Holimitox network members
Laurence Huc is a toxicologist. She works on environmental carcinogenesis, in relation to exposure to pollutants (polycyclic aromatic hydrocarbons, dioxins, pesticide mixtures, SDHI). After 14 years in the Toxalim unit of INRAE in Toulouse, she joined David Demortain’s group at LISIS and Dominique Lagadic-Gossmann’s team at the Institut de recherche en santé, environnement et travail (Irset, Inserm UMR_S 1085) in Rennes. She is developing a research programme combining biology and human and social sciences on the production of knowledge for public action on environmental health, and more specifically on the standards of proof of the existence of risks of pesticides for human health. It coordinates 5 national programmes (ANR, FRM, Fondation ARC, Ligue contre le Cancer, Ecophyto2+-OFB). It set up the multidisciplinary scientific network Holimitox in 2020 to address the issue of SDHI use from an EcoHealth approach. |
Main publications
Bénit P, Kahn A, Chretien D, Bortoli S, Huc L, Schiff M, Gimenez-Roqueplo AP, Favier J, Gressens P, Rak M, Rustin P. Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells.PLoS One. 2019 Nov 7;14(11):e0224132. doi: 10.1371/journal.pone.0224132. eCollection 2019.
Martin OCB, Olier M, Ellero-Simatos S, Naud N, Dupuy J, Huc L, Taché S, Graillot V, Levêque M, Bézirard V, Héliès-Toussaint C, Estrada FBY, Tondereau V, Lippi Y, Naylies C, Peyriga L, Canlet C, Davila AM, Blachier F, Ferrier L, Boutet-Robinet E, Guéraud F, Théodorou V, Pierre FHF. Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation. Microbiome. 2019 May 6;7(1):72. doi: 10.1186/s40168-019-0685-7.
Bortoli, S., Boutet-Robinet, E., Lagadic-Gossmann, D., Huc, L. (2018). Nrf2 and AhR in metabolic reprogramming after contaminant exposure. Current Opinion in Toxicology, 2018, 8:34–41, DOI : 10.1016/j.cotox.2017.12.001 Review
Boutet-Robinet, E., Bortoli, S., Huc, L. (2018). DNA damage response upon environmental contaminants: an exhausting work for genomic integrity. Current Opinion in Toxicology, 8, 28-33. , DOI : 10.1016/j.cotox.2017.12.002 Review
Saunier E, Antonio S, Regazzetti A, Auzeil N, Laprévote O, Shay JW, Coumoul X, Barouki R, Benelli C, Huc L, Bortoli S. Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells. Sci Rep. 2017 Jul 31;7(1):6945. doi: 10.1038/s41598-017-07006-0. PubMed PMID: 28761044;
Hardonnière K, Huc L, Sergent O, Holme JA, Lagadic-Gossmann D. Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism. Semin Cancer Biol. 2017 Apr;43:49-65. doi: 10.1016/j.semcancer.2017.01.001. Epub 2017 Jan 11. Review. PubMed PMID: 28088583.
Hardonnière K, Saunier E, Lemarié A, Fernier M, Gallais I, Héliès-Toussaint C, Mograbi B, Antonio S, Bénit P, Rustin P, Janin M, Habarou F, Ottolenghi C, Lavault MT, Benelli C, Sergent O, Huc L*, Bortoli S, Lagadic-Gossmann D. *co-dernière auteure The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival. Sci Rep. 2016 Aug 4;6:30776. doi: 10.1038/srep30776. PubMed PMID: 27488617; PubMed Central PMCID: PMC4973274.
Graillot V, Dormoy I, Dupuy J, Shay JW, Huc L, Mirey G, Vignard J. Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis. Corresponding author, Front Cell Infect Microbiol. 2016 Mar 23;6:34. doi: 10.3389/fcimb.2016.00034. eCollection 2016 PubMed PMID: 27047802; PubMed Central PMCID: PMC4803749.
Surya R, Héliès-Toussaint C, Martin OC, Gauthier T, Guéraud F, Taché S, Naud N, Jouanin I, Chantelauze C, Durand D, Joly C, Pujos-Guillot E, Pierre FH, Huc L. Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats. Carcinogenesis. 2016 Jun;37(6):635-645. doi:10.1093/carcin/bgw035. Epub 2016 Mar 18. PubMed PMID: 26992899.
Hardonnière K, Huc L, Podechard N, Fernier M, Tekpli X, Gallais I, Sergent O, Lagadic-Gossmann D. Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential. Toxicol In Vitro. 2015 Oct;29(7):1597-608. doi: 10.1016/j.tiv.2015.06.010. Epub 2015 Jun 15. PubMed PMID: 26086121.
François Chamaraux made a PhD in biophysics (“Cell motility driven by actin polymerization : some experimental and theoretic aspects »). He divides his activities between teaching on the one hand (physics and mathematics, ULB/EPFC, Brussels), and scientific mediation on the other hand (general scientific papers, workshops intended for general public, adults and children.). Since 2021, he is scientific writer for the group Holimitox. |
Rémy Ballot is an agronomist. Member of the JRU “Agronomie” at INRAE Grignon, he support public decision making toward agroecology. Part of his activities consists in describing current agricultural prac-tices, based on public data analysis. He also support local concer-tations at the scale of agricultural territories, based on scenario design to represent and assess the evolution of agrifood systems. |
List of publications 5-10 relevant publications relative of Holimitox network:
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Rémy Ballot, Marie Thiollet-Scholtus, Marie-Helene Jeuffroy. Current on-farm glyphosate uses and alternative practices in France. 6th International Symposium for Farming System Design, Universidad de la República Uruguay. URY., 2019, Montevideo, France. ⟨hal-02737355⟩
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BALLOT Rémy, GUILPART Nicolas, PELZER Elise, & JEUFFROY Marie-Hélène. (2019, October). Current dominant crop sequences across EU: a typology based on LUCAS dataset. Presented at the European Conference on Crop Diversification (ECCD), Budapest, Hungary: Zenodo. http://doi.org/10.5281/zenodo.3492238
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Anses. 2018. Risques et bénéfices relatifs des alternatives aux produits phytopharmaceutiques comportant des néonicotinoïdes Tome 3 – Rapport d’appui scientifique et technique sur l’impact agricole. Avis et rapport de l’Anses. Maisons-Alfort, 148 p. Rapporteurs : Ballot R., Desquilbet M., Garnon P., Reboud X.
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Ballot R., Chauvel B., Guichard L. How corn is cultivated in France ? A cropping systems typology to support public decision making on genetically modified cultivars. Poster session presented at: Managing global resources for a secure future. nternational ASA, CSSA, and SSSA Annual Meeting, Oct. 22-25, in Tampa, FL.
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Ballot, R., Loyce, C., Jeuffroy, M.-H., Ronceux, A., Gombert, J., Lesur-Dumoulin, C., Guichard, L., 2018. First cropping system model based on expert-knowledge parameterization. Agron. Sustain. Dev. 38. https://doi.org/10.1007/s13593-018-0512-8
Erwan Bezard, INSERM Research Director, has authored or co-authored over 300 professional publications (h = 86) in the field of neurobiology, most of which are on Parkinson’s disease and related disorders. He has funded in 2010, and headed until 2020, a CNRS research unit located in Bordeaux, the Institute of Neurodegenerative Diseases, which features preclinical and clinical researchers working towards development of therapeutic solutions. He serves on the board of international organizations such as the Michael J. Fox Foundation and Parkinson’s UK. He is Associate Editor of Neurobiology of Disease, a leading journal in the field and serves on the editorial boards of several other neurobiology journals. |
Publications : 314 (https://pubmed.ncbi.nlm.nih.gov/?term=bezard+e&sort=date )
h index: 85 (Google) – i10: 240 – 23589 citations (https://scholar.google.com/citations?user=18uc7IMAAAAJ&hl=fr&oi=ao )
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Fridjonsdottir, R. Shariatgorji, A. Nilsson, T. Vallianatou, L.R. Odell, L. Schembri, P. Svenningsson, P.O. Fernagut, A.R. Crossman, E. Bezard*, P.E. Andrén. Mass spectrometry imaging identifies abnormally elevated brain L-DOPA levels and extra-striatal monoaminergic dysregulation in L-DOPA-induced dyskinesia. Science Advances 2021, 7 : eabe5948 (co-last author) (Cover Highight)
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De Giorgi, F. Laferrière, Federica Zinghirino, E. Faggiani, A. Lends, Mathilde Bertoni, Xuan Yu, A. Grélard, E. Morvan, B. Habenstein, N. Dutheil, E. Doudnikoff, J. Daniel, S. Claverol, C. Qin, A. Loquet, E. Bezard, F. Ichas. Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons. Science Advances 2020, 6(40): eabc4364.
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N. Soria, C. Paviolo, E. Doudnikoff, M.L. Arotcarena, A. Lee, N. Danné, A.K. Mandal, P. Gosset, B. Dehay, L. Groc, L. Cognet and E. Bezard. Synucleinopathy alters nanoscale organization and diffusion of the brain extracellular space through hyaluronan remodeling. Nature communications 2020, 11: 3440. https://doi.org/10.1038/s41467-020-17328-9 Highlighted by editor: https://www.nature.com/ncomms/editorshighlights and subject of a focus: https://www.nature.com/collections/mjkksldswr
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Bourdenx, A. Nioche, S. Dovero, M.L. Arotcarena, S. Camus, G. Porras, M.L. Thiolat, N.P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N.N. Vaikath, O.M.A. El-Agnaf, M.T.Herrero, P. Derkinderen, M. Vila, J.A. Obeso, B. Dehay and E. Bezard. Machine learning reveals different pathological signatures of patient-derived alpha-synuclein extracts in non-human primates. Science Advances 2020, DOI : 10.1126/sciadv.aaz9165.
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L. Arotcarena, S. Dovero, A. Prigent, M. Bourdenx, S. Camus, G. Porras, M.L. Thiolat, M. Tasselli, P. Aubert, N. Kruse, B. Mollenhauer, I. Trigo Damas, C. Estrada, N. Garcia-Carrillo, N.N. Vaikath, O.M.A. El-Agnaf, M.T. Herrero, M. Vila, J.A. Obeso, P. Derkinderen, B. Dehay and E. Bezard. Bidirectional gut-to-brain and brain-to-gut propagation of α-synuclein pathology in non-human primates. Brain 2020, 43: 1462-1475.
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Capogrosso, T. Milekovic, D. Borton, F. Wagner, E. M. Moraud2, J.-B. Mignardot, N. Buse, J. Gandar, Q. Barraud, D. Xing, E. Rey, S. Duis, Y. Jianzhong, W.K.D. Ko, Q. Li, P. Detemple, T. Denison, S. Micera, E. Bezard, J. Bloch, G. Courtine. A brain–spinal interface alleviating Locomotor deficits after spinal cord injury. Nature 2016, 539 (7628):284-288.
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Porras, A. Berthet, B. Dehay, Q. Li, L. Ladepeche, E. Normand, S. Dovero, A. Martinez, E. Doudnikoff, M.-L. Martin-Négrier, Q. Chuan, B. Bloch, D. Choquet, E. Boué-Grabot, L. Groc and E. Bezard. PSD-95 expression controls L-dopa dyskinesia through Dopamine D1 receptor trafficking. Journal of Clinical Investigation, 2012, 122:3977-3989 – Press release and video interview on JCI website
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Dehay, A. Ramirez, M. Martinez-Vicente, C. Perier, M.H. Canron, E. Doudnikoff, A. Vital, M. Vila, C. Klein and E. Bezard. Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson
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R. Ahmed, A. Berthet, E. Bychkov, G. Porras, Q. Li, B.H. Bioulac, Y.T. Carl, B. Bloch, S. Kook, I. Aubert, S. Dovero, E. Doudnikoff, V.V. Gurevich, E.V. Gurevich and E. Bezard. Lentiviral overexpression of GRK6 alleviates L-DOPA-induced dyskinesia in experimental Parkinson’s disease. Science Translational Medicine 2010, 2 (28) 28ra28 (Highlighted in Cell, 2010, 141:737)
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Bezard, S. Ferry, U. Mach, H. Stark, L. Leriche, T. Boraud, C.E. Gross and P. Sokoloff. Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nature Medicine 2003, 9: 762-767.
Jean-Marc BONMATIN works for CNRS-Center for molecular biophysics, at the interface of chemistry, biology and toxicology. More specifically, he studies 1) exposure to pesticides, and 2) their mechanisms of action and their effects on living systems. This allows him to refine risk assessment for invertebrates, vertebrates and public health. Vice-president of the Task Force on Systemic Pesticides (www.tfsp.info), JM Bonmatin is also a member of national expert committees (Agency of food safety & environment, Institute of bees & pollination, Ministry of agriculture), as well as for international organisations (IUCN, IPBES, OECD).
(2017 – mars 2021)
Desquilbet M, Cornillon PA, Gaume L & Bonmatin JM (2021) Matters arising: Adequate statistical modelling and data selection are essential when analysing abundance and diversity trends, Nature Ecology & Evolution, https://doi.org/10.1038/s41559-021-01427-x
Mahefarisoa KL, Simon Delso N, Zaninotto V, Colin ME & Bonmatin JM (2021) The Threat of Veterinary Medicinal Products and Biocides on Pollinators: A One Health Perspective, One Health, https://doi.org/10.1016/j.onehlt.2021.100237
Desquilbet M, Gaume L, Grippa M, Céréghino R, Humbert JF, Bonmatin JM, Cornillon PA, Maes D. Van Dyck H.& Goulson D (2020) Comment on “Meta-analysis reveals declines in terrestrial but increases in freshwater insect abundances”, Science, 370 (6523), eabd8947, http://science.sciencemag.org/content/370/6523/eabd8947
Bonmatin J-M, Mitchell EAD, Glauser G, Lumawig-Heitzman E, Claveria F, Bijleveld van Lexmond M, Taira K and Sánchez-Bayo F (2020) Residues of neonicotinoids in soil, water and people’s hair: a case study from three agricultural regions of the Philippines, Science of The Total Environment, 143822, https://doi.org/10.1016/j.scitotenv.2020.143822
Wyckhuys KAG, Aebi A, Bijleveld van Lexmond MFIJ., Bojaca CR, Bonmatin J-M, Furlan L, Guerrero JA, Mai TV, Pham HV, Sanchez-Bayo F, Ikenaka Y (2020) Resolving the twin human and environmental health hazards of a plant based diet, Environment International, 144, 106081, https://doi.org/10.1016/j.envint.2020.106081
Veres A, Wyckhuys KAG, Kiss J, Tóth F, Burgio G, Pons X, Avilla C, Vidal S, Razinger J, Bazok R, Matyjaszczyk E, Milosavljević I, Vi LX, Zhou W, Zhu Z, Tarno H, Hadi B, Lundgren J, Bonmatin JM, Bijleveld van Lexmond M, Aebi A, Rauf A, Furlan L (2020) An update of the Worldwide Integrated Assessment (WIA) on systemic pesticides. Part 4: Alternatives in major cropping systems, Environ. Sci. Pollut. Res., 27, pages29867–29899 https://link.springer.com/article/10.1007/s11356-020-09279-x
Ichikawa G, Kuribayashi R, Ikenaka Y, Ichise T, Nakayama SMM, Ishizuka M, Taira K, Fujioka K, Sairenchi T, Kobashi G, Bonmatin JM, Yoshihara S (2019) LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth. PLoS ONE, 14(7): e0219208. https://doi.org/10.1371/journal.pone.0219208
Bonmatin JM, Noome D, Moreno H, Mitchell E, Glauser G, Soumana OS, Bijleveld van Lexmond M & Sanchez-Bayo F (2019). A survey and risk assessment of neonicotinoids in water, soil and sediments of Belize, Env. Pollut., https://doi.org/10.1016/j.envpol.2019.03.099
Furlan L, Pozzebon A, Duso C, Simon-Delso N, Sánchez-Bayo F, Bijleveld van Lexmond M, Bonmatin JM (2018). An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 3: Alternatives to systemic insecticides. Environ Sci Pollut Res. 28, pages11798–11820 https://link.springer.com/article/10.1007/s11356-017-1052-5
Pisa L, Goulson D, Yan EC, Gibbons D, Sánchez-Bayo F, Mitchell E, van der Sluijs J, MacQuarrie C, Giorio C, Long EY, McField M, Bijleveld van Lexmond M, Bonmatin JM (2017). An update of the World Integrated Assessment (WIA) on systemic insecticides. Part 2: Impacts on organisms and ecosystems. Environ. Sci. Pollut. Res., 28, pages11749–11797 https://link.springer.com/article/10.1007/s11356-017-0341-3
Giorio C, Anton Safer A, Sánchez-Bayo F, Tapparo A, Lentola A, Girolami V, Bijleveld van Lexmond M, Bonmatin J-M (2017). An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 1: New molecules, metabolism, fate and transport. Environ. Sci. Pollut. Res., 28, pages11716–11748. https://link.springer.com/article/10.1007/s11356-017-0394-3
Sánchez-Bayo F, Belzunces L, Bonmatin JM (2017) Lethal and sublethal effects, and incomplete clearance of ingested imidacloprid in honey bees (Apis mellifera). Ecotoxicology, 26, 1199-206 https://link.springer.com/article/10.1007/s10646-017-1845-9
Frédéric Delbac is Professor in Microbiology and the head of the team “Interactions Hôtes-Parasites” at “Laboratoire Microorganismes Génome et Environnement (LMGE UMR UCA-CNRS 6023), Clermont Auvergne University, Clermont-Ferrand. His main research projects concern microsporidia, some obligate intracellular parasites infecting a diverse range ofhost from insects to mammals and has been working on honeybees since 2008. He has managed different research programs focusing on the microsporidian Nosema ceranae and its impact on honey bee health, and has a strong interest on the interactions of these gut parasites with different chemical stressors including insecticides, fungicides and herbicides. |
Main publications
Jousse C, Dalle C, Abila A, Traikia M, Diogon M, Lyan B, El Alaoui H, Vidau C, Delbac F (2020) A combined LC-MS and NMR approach to reveal metabolic changes in the hemolymph of honeybees infected by the gut parasite Nosema ceranae. Journal of Invertebrate Pathology 176:107478. doi: 10.1016/j.jip.2020.107478.
Paris L, Peghaire E, Moné A, Diogon M, Debroas D, Delbac F, El Alaoui H (2020) Honeybee gut microbiota dysbiosis in pesticide/parasite co-exposures is mainly induced by Nosema ceranae. Journal of Invertebrate Pathology 172:107348. doi: 10.1016/j.jip.2020.107348.
Peghaire E, Moné A, Delbac F, Debroas D, Chaucheyras-Durand F, El Alaoui H (2020) A Pediococcus strain to rescue honeybees by decreasing Nosema ceranae– and pesticide-induced adverse effects. Pesticide Biochemistry and Physiology 163:138-146. doi: 10.1016/j.pestbp.2019.11.006.
Rouzé R, Moné A, Delbac F, Belzunces L, Blot N (2019) The honeybee gut microbiota is altered after chronic exposures to different families of insecticides and infection by Nosema ceranae. Microbes and Environments25;34(3):226-233.
Panek J, Paris L, Roriz D, Mone A, Dubuffet A, Delbac F, Diogon M, El Alaoui H. (2018) Impact of the microsporidian Nosema ceranae on the gut epithelium renewal of the honeybee, Apis mellifera. Journal of Invertebrate Pathology 159:121-128.
Paris L, El Alaoui H, Delbac F, Diogon M. (2018) Effects of the gut parasite Nosema ceranae on honey bee physiology and behavior. Current Opinion in Insect Science, 26:149-154.
Paris L, Roussel M, Pereira B, Delbac F, Diogon M. (2017) Disruption of oxidative balance in the gut of the western honeybee Apis mellifera exposed to the intracellular parasite Nosema ceranae and to the insecticide fipronil. Microbial Biotechnology 10(6):1702-1717.
Roussel M, Villay A, Delbac F, Michaud P, Laroche C, Roriz D, El Alaoui H, Diogon M. (2015) Antimicrosporidian activity of sulphated polysaccharides from algae and their potential to control honeybee nosemosis. Carbohydrate Polymers 133:213-20.
Vidau C, Panek J, Texier C, Biron DG, Belzunces LP, Le Gall M, Broussard C, Delbac F, El Alaoui H. (2014) Differential proteomic analysis of midguts from Nosema ceranae-infected honeybees reveals manipulation of key host functions. Journal of Invertebrate Pathology, 121: 89-96.
Aufauvre J, Misme-Aucouturier B, Viguès B, Texier C, Delbac F, Blot N. (2014) Transcriptome Analyses of the Honeybee Response to Nosema ceranae and Insecticides. PLoS One, 9(3):e91686.
David Demortain is a sociologist and political scientist, INRAE research professor and head of the Laboratoire Interdisciplinaire Sciences Innovations Sociétés (LISIS). He conducts research in the area of science and technology studies, looking at the politics of expertise and regulatory knowledge, with a special interest in the construction of regulatory sciences such as toxicology and the regulation of chemicals. He is an associate fellow of the Institute for Research on Innovation and Society, and of the Centre for Analysis of Risk and Regulation of the London School of Economics. |
Main publications
Demortain, D. (2013). Regulatory Toxicology in Controversy. Science, Technology & Human Values, 38(6), 727‑748.
Demortain, D. (2017). Expertise, Regulatory Science and the Evaluation of Technology and Risk : Introduction to the Special Issue. Minerva, 55(3), 139‑159.
Demortain, D. (2021). Être chercheur, devenir expert ?. L’économie morale du rapport à l’expertise dans un laboratoire de toxicologie. Revue d’anthropologie des connaissances, 15(15‑1), Article 1. http://journals.openedition.org/rac/19302
Demortain, D., & Borraz, O. (s. d.). Managing technical reputation : Regulatory agencies and evidential work in risk assessment. Public Administration, n/a(n/a). https://doi.org/10.1111/padm.12734
Demortain, D., & Boullier, H. (2019). Scientific expertise in the marketplace : Market expectations and the construction of toxicology methods in chemicals regulation in the United States. Revue Francaise de Sociologie, Vol. 60(3), 429‑456.
Colette Denis is Associate Professor in Animal Physiology at University Paul Sabatier, Toulouse. From 1983 to 1990 she worked on the regulation of glycolysis and proliferation in intestinal adenocarcinoma cells, and from 1990 to 2014 she specialized in molecular pharmacology. Since 2015, she is principal investigator at the Renal Fibrosis Lab, INSERM U1297, where she works on the validation of animal models of kidney fibrosis and the design of therapeutic targets for chronic kidney disease and acute kidney injury. |
Selected publications
Schaak, D. Cussac, C. Cayla, J.C. Ddevedjian, R. Guyot, H. Paris & C. Denis. Alpha2-adrenoceptors regulate proliferation of human intestinal epithelial cells. Gut, 2000, 47, 242-250
C. Denis, A. Saulière, S. Galandrin, JM Senard & C. Galés. Probing heterotrimeric G protein activation: applications to biased ligands. Curr. Pharm. Des. 2012, 18, 128-44.
A. Saulière, M. Bellot, H. Paris, C. Denis, F. Finana, J. T. Hansen, M.F. Altié, M.H. Seguelas, J.L. Hansen, J.M. Sénard & C. Galés. Delineating the complexity of biased and full agonism reveals the existence of a new distinct active AT1 receptor entity. Nat. Chem. Biol. 2012, 8, 622-30.
S. Galandrin, C. Denis, C. Boularan, J. Marie, C. M’Kadmi, C. Pilette, C. Dubroca, Y. Nicaise, MH. Seguelas, D. N’Guyen, JL. Banères, A. Pathak, JM. Sénard & C. Galés. Cardioprotective Angiotensin-(1-7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 Receptor. Hypertension. 2016, 68, 1365-1374.
K. Mirzoyan, C. Denis, A. Casemayou, S. Faguer, M. GilLet, D. Marsal, JL. Bascand, JP. SchanstrA & JP. Saulnier-Blache. Lysophosphatidic acid protects against endotoxin-induced acute kidney injury. Inflammation 2017, 40, 1707-1716.
C. Vinel, J. P. Schanstra, F. Boizard, O. Péreira, J. Auriau, A. Dortignac, B. Breuil, G. Feuillet, E. Nkuipou-Kenfack, P. Zürbig, P. Valet, J.L. Bascands, C. Dray & C. Denis. Apelin affects the mouse aging urinary peptidome with minimal effects on kidney. Scientific Reports, 2019, 9,10647. doi: 10.1038/s41598-019-47109-4.
J. Klein, C. Caubet, M. Camus, M. Makridakis, C. Denis, M. Gilet, G. Feuillet, S. Rascalou, E. Neau, L. Garrigues, O. Thillaye du Boullay, H. Mischak, O. Burlet-Schiltz, A. Vlahou, J.S. Saulnier-Blache, J.L. Bascands, J.P. Schanstra. Connectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney disease. Scientific Reports, 2020. 10:14898. doi: 10.1038/s41598-020-71950-7.
Marion Desquilbet is a research fellow at INRAE and in the environmental and natural resource economics group of Toulouse School of Economics (university Toulouse Capitole). Her research focuses on the impacts of different types of agricultural production and the analysis of public policies that govern them. She is a member of the Scientific Council of the National Agency for Food, Environmental and Occupational Health Safety (Anses) and has taken part in expert assessments for the High Council of Biotechnology, Anses and the High Council of Public Health in France. |
Selected publications
Desquilbet M., Cornillon P.A., Gaume L., Bonmatin J.M. (2021). Adequate statistical modelling and data selection are essential when analysing abundance and diversity trends, Matters Arising, arising from M. S. Crossley et al. https://doi.org/10.1038/s41559-020-1269-4 (2020). Nature Ecology & Evolution, doi.org/10.1038/s41559-021-01427-x.
Desquilbet M., Gaume L., Grippa M., Céréghino R., Humbert J.F., Bonmatin J.M., Cornillon P.A., Maes F., Van Dyck H., Goulson D. (2020). Comment on “Meta-analysis reveals declines in terrestrial but increases in freshwater insect abundances”, Science, 10.1126/science.abd8947.
Loconto A., Desquilbet M., Moreau T., Couvet D., Dorin B. (2020). The Land sparing – Land sharing controversy: tracing the politics of knowledge. Land Use Policy, 96, 103610.
Desquilbet M., Bullock D.S., D’Arcangelo F.M. (2019). A discussion of the market and policy failures associated with the adoption of herbicide-tolerant crops. International Journal of Agricultural Sustainability, 17, 326-337.
Desquilbet M., Maigné E., Monier-Dilhan S. (2018). Organic food retailing and the conventionalisation debate.Ecological Economics, 150, 194-203.
Anses. 2018. Risques et bénéfices relatifs des alternatives aux produits phytopharmaceutiques comportant des néonicotinoïdes Tome 3 – Rapport d’appui scientifique et technique sur l’impact agricole. Avis et rapport de l’Anses. Maisons-Alfort, 148 p. Rapporteurs : Ballot R., Desquilbet M., Garnon P., Reboud X.
Desquilbet M., Dorin B., Couvet D. (2017). Land sharing vs. land sparing for biodiversity: How agricultural markets make the difference. Environmental Modeling & Assessment, 22, 188-200.
Desquilbet M., Herrmann M. (2016). The dynamics of pest resistance management: the case of refuge fields for Bt crops. Canadian Journal of Agricultural Economics, 64, 253-288.
Desquilbet M., Baret P., Butault J.-P., Chauvel B. (2015). Proposition d’un cadre méthodologique pour l’évaluation socio-économique des plantes génétiquement modifiées. Rapport pour le Haut Conseil des Biotechnologies, Juillet.
Ambec S., Desquilbet M. (2012). Regulation of a spatial externality: refuges versus tax for managing pest resistance. Environmental and Resource Economics, 51, 79-104.
Since 2008 I have been working on microsporidia, intracellular fungi-related parasites that infect different animal species. More specifically, I study the microsporidia Nosema ceranae, which is a honeybee gut pathogen. I am trying to understand the impact of this microsporidia on the honeybee health but also the impact of this parasite combined with different pesticides at sub-lethal and environmental doses (insecticides, fungicides, herbicides). |
Selected publications
Fernandes, V., Hidalgo, K., Diogon, M., Mercier, F., Angénieux, M., Ratel, J., Delbac, F., Engel, E., Bouchard, P. (2023) A GABA Receptor Modulator and Semiochemical Compounds Evidenced using Volatolomics as Candidate Markers of Chronic Exposure to Fipronil in Apis mellifera. Metabolites, 13, 185.https://doi.org/10.3390/metabo13020185
Pal, E., Almasri, H., Paris, L., Diogon, M., Pioz, M., Cousin, M., Sené, D., Tchamitchian, S., Tavares, D.A., Delbac, F., Blot, N., Brunet, J-L., Belzunces, L. (2022). Toxicity of the Pesticides Imidacloprid, Difenoconazole and Glyphosate Alone and in Binary and Ternary Mixtures to Winter Honey Bees: Effects on Survival and Antioxidative Defenses. Toxics, 10, 104. https://doi.org/10.3390/toxics10030104
Almasri, H., Tavares, D.A., Diogon, M., Pioz, M., Alamil, M., Sené, D., Tchamitchian, S., Cousin, M., Brunet, J-L., Belzunces, L. (2021). Physiological effects of the interaction between Nosema ceranae and sequential and overlapping exposure to glyphosate and difenoconazole in the honey bee Apis mellifera. Ecotoxicology and Environmental Safety.
Jousse C, Dalle C, Abila A, Traikia M, Diogon M, Lyan B, El Alaoui H, Vidau C, Delbac F. (2020). A combined LC-MS and NMR approach to reveal metabolic changes in the hemolymph of honeybees infected by the gut parasite Nosema ceranae. J Invertebr Pathol. 107478.
Paris, L., Peghaire, E., Moné, A., Diogon, M., Debroas, D., Delbac, F., El Alaoui, H. (2020). Pesticides and Nosema ceranae : an association that contributes to disturb the gut microbiota of the western honeybee Apis mellifera. Journal of invertebrate pathology. 107348
Panek, J., Paris, L., Roriz, D., Moné, A., Dubuffet, A., Delbac, F., Diogon, M., El Alaoui, H. (2018). Impact of the microsporidian Nosema ceranae on the gut epithelium renewal of the honeybee, Apis mellifera. Journal of invertebrate pathology, 159, 121-128.
Paris L., El Alaoui, H., Delbac, F., Diogon, M. (2018) Effects of the gut parasite ceranae on honey bee physiology and behavior. Current Opinion in Insect Science, 26, 149-154.
Paris L., Roussel M., Pereira B., Delbac F., Diogon M. (2017) Disruption of the oxidative balance in the gut of the honeybees Apis mellifera exposed to the intracellular parasite Nosema ceranae and to the insecticide fipronil. Microbial Biotechnology, 10(6), 1702-1717.
Roussel M, Villay, Delbac F, Michaud P, Laroche C, Roriz D, El Alaoui H, Diogon M. (2015). Antimicrosporidian activity of sulphated polysaccharides from algae and their potential to control honeybee nosemosis. Carbohydrate polymers, 133, 213-220
Judith Favier, INSERM Research Director, is the head of the ‘Genetics and Metabolism of Rare Cancers’ lab in the PARCC (INSERM UMR970). She is an internationally recognized expert of inherited pheochromocytoma and paraganglioma and in particular, of the biology of SDH-mutated tumors. She has made pioneering discoveries in the field, demonstrating their link with pseudo-hypoxia, angiogenesis, epithelial-to-mesenchymal transition and epigenetic modifications. She authored 98 publications and gave 50 conferences in the past 10 years. She is the previous chair of the international Pheochromocytoma Research Support Organization, a member of the scientific board of the European Network for the Study of Adrenal Tumors (ENS@T) and an Associate Editor at the Endocrine-related Cancer journal. |
Selected publications
Morin A, Goncalves J, Moog S, Buffet, Castro-Vega LJ, Woszczyk J, Fontenille MJ, Gimenez-Roqueplo AP, #Letouzé E and #Favier J. TET-mediated hypermethylation primes SDH-deficient cells for HIF2a driven mesenchymal transition. Cell Reports 2020; 30(13):4551-4566.e7.
Lussey-Lepoutre C, Bellucci A, Burnichon N, Amar L, Buffet A, Drossart T, Fontaine S, Clément O, Benit P, Rustin P, Groussin L, Meatchi T, Gimenez-Roqueplo AP, Tavitian B and Favier J. Succinate detection by in vivo 1H-MR spectroscopy identifies germline and somatic SDHx mutations in paragangliomas. Eur J Nucl Med Mol Imaging 2020 ;47(6):1510-1517.
*Job S, *Draskovic I, *Burnichon B, Buffet A, Padilla-Girola M, Venisse A, Robidel E, Cros J, Badoual C, Verkarre V, Sibony M, Amar L, de Reyniès A, Bertherat J, Arturo Londoño-Vallejo A, #Favier J, #Castro-Vega LJ and #Gimenez-Roqueplo AP. Telomerase Activation and ATRX Mutations Are Independent Risk Factors for Metastatic Pheochromocytoma and Paraganglioma. Clin Cancer Res, 2019 ;25(2):760-770.
Favier J, Amar L, Gimenez-Roqueplo A-P. Paraganglioma and pheochromocytoma: from genetics to personalized medicine. Nature Rev Endocrinol. 2015; 11(2):101-111 (IF 20.2) Invited Review.
*Lussey-Lepoutre C, *Hollinshead KER, Ludwig C, Menara M, Morin A, Castro-Vega LJ, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo AP, #Favier J and #Tennant DA. Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. Nat. Commun. 2015, Nov 2;6:8784.
*Castro-Vega L-J *Letouzé E, *Burnichon N, Buffet A, Disderot P-H, Khalifa E, Loriot C, Elarouci N, Morin A, Ménara M, Lepoutre-Lussey C, Badoual C, Sibony M, Dousset B, Libé R, Zinzindohoue F, Plouin P-F, Bertherat J, Amar L, de Reyniès A, #Favier J and #Gimenez-Roqueplo A-P. Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas. Nat. Commun. 2015 ; 6:6044.
*Letouzé E, *Martinelli C, Loriot C, Burnichon N, Abermil N, Ottolenghi C, Janin M, Menara M, Nguyen AT, Benit P, Buffet A, Marcaillou C, Bertherat J, Amar L, Rustin P, De Reyniès A, #Gimenez-Roqueplo AP and #Favier J. SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell, 2013 ; 23(6):739-52 (IF 22.8).
8.*van Nederveen FH, *Gaal J, *Favier J, Korpershoek E, Oldenburg RA, de Bruyn EM, Sleddens HF, Derkx P, Rivière J, Dannenberg H, Petri BJ, Komminoth P, Pacak K, Hop WC, Pollard PJ, Mannelli M, Bayley JP, Perren A, Niemann S, Verhofstad AA, de Bruïne AP, Maher ER, Tissier F, Méatchi T, Badoual C, Bertherat J, Amar L, Alataki D, Van Marck E, Ferrau F, François J, de Herder WW, Peeters MP, van Linge A, Lenders JW, Gimenez-Roqueplo AP, de Krijger RR, Dinjens WN. An easy and low-cost routine immunohistochemical procedure for the detection of Paraganglioma and Pheochromocytoma patients with germline SDHB, C or D gene mutations. Lancet Oncol 2009 10(8): 764-71.
Gimenez-RoqueploAP, Favier J, Rustin P, Rieubland C, Crespin M, Nau V, Kau Van Khien P, CorvolP, Plouin PF, and Jeunemaitre X. Mutations in the SDHB gene are associated with extra-adrenal and/or malignant pheochromocytomas. Cancer Res 2003 ; 63 : 5615–5621.
10.Gimenez-Roquelo AP, Favier J, Rustin P, Mourad JJ, Plouin PF, Corvol P, Rötig A, and Jeunemaitre X. The R22X mutation in the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am J Hum Genet 2001; 69(6):1186-97
Graduated from a professional license in 2021, I did a work-study in the RESTORE laboratory in Toulouse under the supervision of Dr Audrey VARIN. I studied the immunoregulatory capacities of mesenchymal stromal cells isolated from subcutaneous adipose tissue and from the adipose body of the mouth.
Since September 2021, I am a research technician at the Toulouse Cancer Research Center (CRCT, UMR1037 Inserm – Toulouse 3 University – ERL5294 CNRS). I work under the supervision of Anthony LEMARIE on the impact of SDHI pesticides on the mitochondrial metabolism of glioblastoma stem cells and neural progenitors. |
Séverine Jean est maître de conférences au Laboratoire d’Ecologie Fonctionnelle et Environnement (CNRS/INPT/UPS), INP-ENSAT de l’Université de Toulouse. Elle est spécialisée en écophysiologie et écotoxicologie. Ses travaux portent sur l’impact de stress environnementaux, comme la pollution, sur les poissons sauvages ou d’élevage aux différentes échelles d’organisation depuis la molécule jusqu’aux populations. Elle est membre du Comité Scientifique du programme EC2CO (CNRS INSU) dans l’axe thématique DYCOVI (DYnamique des COntaminants et interactions avec le VIvant). |
Selected publications
Petitjean Q., Jacquin L., Riem L., Cousseau M., Perrault A., Laffaille P., Jean S. (2020). Intraspecific variability of responses to metal contamination and immune challenge across wild gudgeon populations. Environmental Pollution, 272, 116042. DOI: 10.1016/j.envpol.2020.116042
Petitjean Q., Jean S., Côte J., Perrault A., Laffaille P., Jacquin L., (2020). Direct and indirect effects of environmental stressors on fish health in human-altered rivers. Science of the Total Environment, 742, 140657. DOI: 10.1016/j.scitotenv.2020.140657
Jacquin L., Petitjean Q., Côte J., Laffaille P., Jean S., (2020). Effects of pollution on fish behavior and cognition: some research perspectives. Frontiers in Ecology & Evolution. 8, 86. Highlighted in Psychology today
Petitjean Q., Jean S., Gandar A., Côte J., Laffaille P., Jacquin L., (2019) Stress responses in fish: From molecular to evolutionary processes. Science of the total environment, 684: 371-380. https://doi.org/10.1016/j.scitotenv.2019.05.357
Acolas ML., Davail B., Gonzalez P., Jean S., Clérandeau C., Morin B., Gourves P.Y., Daffe G., Labadie P., Perrault A., Lauzent M., Pierre M., Le Barh R., Baudrimont M., Peluhet L., Le Menach K., Budzinski H., Rochard E., Cachot J. (2019) Health indicators and contaminant levels of a critically endangered species in the Gironde estuary, the European sturgeon. Environ Sci Poll Res https://doi.org/10.1007/s11356-019-05139-5
Jacquin L., Gandar A., Aguirre-Smith M., Perrault A., Le Hénaff M., De Jong L., Paris-Palacios S., Laffaille P., Jean S. (2019) High temperature aggravates the effects of pesticides in goldfish. Ecotoxicol Environ Saf. 172 : 255- 264.
Hansson S.V., Sonke J., Galop D., Bareille G., Jean S., Le Roux G. (2017) Transfer of marine mercury to mountain lakes. Sci Rep. 7:12719.
Gandar A., Laffaille P., Canlet C., Tremblay-Franco M., Gautier R., Perrault A., Gress L., Mormède P., Tapie N., Budzinski H., Jean S. (2017) Adaptive response under multiple stress exposure in fish: From the molecular to individual level. Chemosphere 188, 60-72.
Gandar A., Laffaille P., Marty-Gasset N., Viala D., Molette C., Jean S. (2017) Proteome response of fish under multiple stress exposure: Effects of pesticide mixtures and temperature increase. Aquat Toxicol. 184: 61-77
Polard T., Jean S., Gauthier L., Laplanche C., Merlina G., Sánchez-Pérez J.M., Pinelli E. (2011). Mutagenic impact on fish of runoff events in agricultural areas in south-west France. Aquat Toxicol. 101:126-134.
Marie Kerhoas is a PhD student supervised by Laurence Huc of the “Contaminants and cellular stress” team at INRAE Toxalim UMR 1331 unit in Toulouse and co-supervised by Olivier Fardel of the “Environmental contaminants and the pulmonary barrier” team at INSERM IRSET UMR 1085 unit in Rennes. She is a pharmacist and she studies the mechanisms of toxicity of succinate dehydrogenase inhibitor fungicides and their carcinogenic potential on human cells lines. |
Selected publications
Yadav, A., Verhaegen, S., Verbruggen, E., Kerhoas, M., Willemijn Huiberts, E. H., Hadera, M. G., Berntsen, H. F., Zimmer, K. E., Ropstad, E., & Paulsen, R. E. (2021). A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro. Reproductive Toxicology, 100, 109‑119. https://doi.org/10.1016/j.reprotox.2021.01.008
Dominique Lagadic-Gossmann is Research Director at CNRS and PI of the Inserm team «Stress, Membrane and Signalling» within IRSET/UMR Inserm 1085 (University of Rennes 1). Cell physiologist by training, she has been developing research in the field of environmental molecular toxicology for the past 20 years, in particular on polycyclic aromatic hydrocarbons and endocrine disruptors. Her team is notably interested in the non-genotoxic effects induced by environmental carcinogens, related to metabolic reprogramming, ionic homeostasis (pH, calcium), membrane remodelling and extracellular vesicles. She was director of the research unit EA 4427 SeRAIC (Signalling and responses to infectious and chemical agents, University of Rennes 1) from 2012 to 2016, and then deputy director of IRSET from 2012 to 2016. She is currently coordinating the AVIESAN METAhCOL project and is a member of the European Oberon consortium (https://oberon-4eu.com/). |
Selected publications
Tête A, Gallais I, Imran M, Legoff L, Martin-Chouly C, Sparfel L, Bescher M, Sergent O, Podechard N, Lagadic-Gossmann D. MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement. Food Chem Toxicol. 2020 Dec;146:111798. doi: 10.1016/j.fct.2020.111798. Epub 2020 Oct 3. PMID: 33022287
2- van Meteren N, Lagadic-Gossmann D, Podechard N, Gobart D, Gallais I, Chevanne M, Collin A, Burel A, Dupont A, Rault L, Chevance S, Gauffre F, Le Ferrec E, Sergent O. Extracellular vesicles released by polycyclic aromatic hydrocarbons-treated hepatocytes trigger oxidative stress in recipient hepatocytes by delivering iron. Free Radic Biol Med. 2020 Nov 20;160:246-262. doi: 10.1016/j.freeradbiomed.2020.08.001. Epub 2020 Aug 10.
3-Brinchmann BC, Le Ferrec E, Bisson WH, Podechard N, Huitfeldt HS, Gallais I, Sergent O, Holme JA, Lagadic-Gossmann D, Øvrevik J. Evidence of selective activation of aryl hydrocarbon receptor nongenomic calcium signaling by pyrene. Biochem Pharmacol. 2018 Dec;158:1-12. doi: 10.1016/j.bcp.2018.09.023. Epub 2018 Sep 22. PMID: 30248327
4- Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, Tête A, Sergent O, Lagadic-Gossmann D, Fromenty B. Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure. Oxid Med Cell Longev. 2018 Jul 26;2018:4396403. doi: 10.1155/2018/4396403. eCollection 2018. PMID: 30147834
5- Hardonnière K, Huc L, Sergent O, Holme JA, Lagadic-Gossmann D. Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism. Semin Cancer Biol. 2017 Apr;43:49-65. doi: 10.1016/j.semcancer.2017.01.001. Epub 2017 Jan 11. PMID: 28088583
6-Hardonnière K, Fernier M, Gallais I, Mograbi B, Podechard N, Le Ferrec E, Grova N, Appenzeller B, Burel A, Chevanne M, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D. Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype. Sci Rep. 2017 Mar 15;7(1):195. doi: 10.1038/s41598-017-00269-7. PMID: 28298645
7- Hardonnière K, Saunier E, Lemarié A, Fernier M, Gallais I, Héliès-Toussaint C, Mograbi B, Antonio S, Bénit P, Rustin P, Janin M, Habarou F, Ottolenghi C, Lavault MT, Benelli C, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D. The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival. Sci Rep. 2016 Aug 4;6:30776. doi: 10.1038/srep30776. PMID: 27488617
8- Hardonnière K, Huc L, Podechard N, Fernier M, Tekpli X, Gallais I, Sergent O, Lagadic-Gossmann D. Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential. Toxicol In Vitro. 2015 Oct;29(7):1597-608. doi: 10.1016/j.tiv.2015.06.010. Epub 2015 Jun 15. PMID: 26086121
9- Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D. Role for membrane remodeling in cell death: implication for health and disease. Toxicology. 2013 Feb 8;304:141-57. doi: 10.1016/j.tox.2012.12.014. Epub 2012 Dec 31. PMID: 23287390
Pierre LEBAILLY Assistant Professor in Public Health at the Normandy University and head of one of the 4 teams of the INSERM Unit ANTICIPE hosted in the Comprehensive Cancer Center François Baclesse in Caen, has authored or co-authored arround 100 professional publications in the field of occupational epidemiology, expology and toxicology, most of which are on cancer. He has funded, in 2005-2007, the largest prospective agricultural cohort worlwide called AGRICAN (more than 181,000 farmers) and he is the principal investigator. He is member of the sterring committee on the AGRICOH consortium held by the International Agency for Research on Cancer. |
Principales publications
1: Bonassi S, Ceppi M, Møller P, Azqueta A, Milić M, Neri M, Brunborg G, Godschalk R, Koppen G, Langie SAS, Teixeira JP, Bruzzone M, Da Silva J, Benedetti D, Cavallo D, Ursini CL, Giovannelli L, Moretti S, Riso P, Del Bo’ C, Russo P, Dobrzyńska M, Goroshinskaya IA, Surikova EI, Staruchova M, Barančokova M, Volkovova K, Kažimirova A, Smolkova B, Laffon B, Valdiglesias V, Pastor S, Marcos R, Hernández A, Gajski G, Spremo-Potparević B, Živković L, Boutet-Robinet E, Perdry H, Lebailly P, Perez CL, Basaran N, Nemeth Z, Safar A, Dusinska M, Collins A; hCOMET project. Author Correction: DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death. Sci Rep. 2021 Sep 20;11(1):19043. doi: 10.1038/s41598-021-98620-6. Erratum for: Sci Rep. 2021 Aug 18;11(1):16793. PMID: 34545156; PMCID: PMC8452740.
2: Togawa K, Leon ME, Lebailly P, Beane Freeman LE, Nordby KC, Baldi I, MacFarlane E, Shin A, Park S, Greenlee RT, Sigsgaard T, Basinas I, Hofmann JN, Kjaerheim K, Douwes J, Denholm R, Ferro G, Sim MR, Kromhout H, Schüz J. Cancer incidence in agricultural workers: Findings from an international consortium of agricultural cohort studies (AGRICOH). Environ Int. 2021 Dec;157:106825. doi: 10.1016/j.envint.2021.106825. Epub 2021 Aug 27. PMID: 34461377; PMCID: PMC8484858.
3: Tual S, Busson A, Boulanger M, Renier M, Piel C, Pouchieu C, Pons R, Perrier S, Levêque-Morlais N, Karuranga P, Lemarchand C; AGRICAN-Group, Marcotullio E, Guizard AV, Monnereau A, Baldi I, Lebailly P. Occupational exposure to pesticides and multiple myeloma in the AGRICAN cohort. Cancer Causes Control. 2019 Nov;30(11):1243-1250. doi: 10.1007/s10552-019-01230-x. Epub 2019 Sep 18. PMID: 31535326.
4: Leon ME, Schinasi LH, Lebailly P, Beane Freeman LE, Nordby KC, Ferro G, Monnereau A, Brouwer M, Tual S, Baldi I, Kjaerheim K, Hofmann JN, Kristensen P, Koutros S, Straif K, Kromhout H, Schüz J. Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium. Int J Epidemiol. 2019 Oct 1;48(5):1519-1535. doi: 10.1093/ije/dyz017. PMID: 30880337; PMCID: PMC6857760.
5: Tual S, Lemarchand C, Boulanger M, Dalphin JC, Rachet B, Marcotullio E, Velten M, Guizard AV, Clin B, Baldi I, Lebailly P. Exposure to Farm Animals and Risk of Lung Cancer in the AGRICAN Cohort. Am J Epidemiol. 2017 Aug 15;186(4):463-472. doi: 10.1093/aje/kwx125. PMID: 28830081.
6: Lemarchand C, Tual S, Boulanger M, Levêque-Morlais N, Perrier S, Clin B, Guizard AV, Velten M, Rigaud E, Baldi I, Lebailly P. Prostate cancer risk among French farmers in the AGRICAN cohort. Scand J Work Environ Health. 2016 Mar;42(2):144-52. doi: 10.5271/sjweh.3552. PMID: 26932763.
7: Baldi I, Carles C, Blanc-Lapierre A, Fabbro-Peray P, Druet-Cabanac M, Boutet-Robinet E, Soulat JM, Bouvier G, Lebailly P; PESTIMAT Group. A French crop-exposure matrix for use in epidemiological studies on pesticides: PESTIMAT. J Expo Sci Environ Epidemiol. 2017 Jan;27(1):56-63. doi: 10.1038/jes.2015.72. Epub 2015 Dec 23. PMID: 26696463.
8: Tual S, Silverman DT, Koutros S, Blair A, Sandler DP, Lebailly P, Andreotti G, Hoppin JA, Freeman LE. Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort. Environ Health Perspect. 2016 May;124(5):611-8. doi: 10.1289/ehp.1409238. Epub 2015 Oct 9. PMID: 26452295; PMCID: PMC4858397.
9: Agopian J, Navarro JM, Gac AC, Lecluse Y, Briand M, Grenot P, Gauduchon P, Ruminy P, Lebailly P, Nadel B, Roulland S. Agricultural pesticide exposure and the molecular connection to lymphomagenesis. J Exp Med. 2009 Jul 6;206(7):1473-83. doi: 10.1084/jem.20082842. Epub 2009 Jun 8. PMID: 19506050; PMCID: PMC2715093.
10: Lebailly P, Bouchart V, Baldi I, Lecluse Y, Heutte N, Gislard A, Malas JP. Exposure to pesticides in open-field farming in France. Ann Occup Hyg. 2009 Jan;53(1):69-81. doi: 10.1093/annhyg/men072. Epub 2008 Nov 20. PMID: 19022871.
Anthony Lemarié is Associate Professor at the Faculty of Pharmaceutical Sciences, Paul Sabatier University, Toulouse (France). A pharmacist by training, he worked between 2002 and 2006 on the impact of metals and metalloids in human toxicity. From 2006 to 2008, he studied the role of complex II of the mitochondrial respiratory chain (Succinate Dehydrogenase) in cell death processes induced by anti-cancer drugs. Since 2009, he has joined the “RADOPT: Radiotherapy Optimization in Glioblastoma” team of the Toulouse Cancer Research Centre (CRCT, UMR1037 INSERM – University of Toulouse 3 – ERL5294 CNRS) and has been working on the involvement of Glioblastoma initiating cells in the radioresistance process. He is particularly interested in the role of tumour metabolic heterogeneity, the microenvironment and the phenotypic and metabolic plasticity of this subpopulation of cancer stem cells in the phenomena of resistance to therapies. The objective of this translational research team is ultimately to transfer the preclinical results obtained to the clinic, within the Radiotherapy Department of the Toulouse University Cancer Institute – Oncopole (UICT-O) to which the research team is attached. |
Selected publications
1: Deshors P, Toulas C, Arnauduc F, Malric L, Siegfried A, Nicaise Y, Lemarié A, Larrieu D, Tosolini M, Cohen-Jonathan Moyal E, Courtade-Saidi M, Evrard SM. Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway. Cell Death Dis. 2019;10(11):816.
2: Malric L, Monferran S, Delmas C, Arnauduc F, Dahan P, Boyrie S, Deshors P, Lubrano V, Da Mota DF, Gilhodes J, Filleron T, Siegfried A, Evrard S, Kowalski-Chauvel A, Moyal EC, Toulas C, Lemarié A. Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells. Mol Cancer Res. 2019;17(2):384-397. PMID: 30266751.
3: Boyrie S, Delmas C, Lemarié A, Lubrano V, Dahan P, Malric L, Luis J, GilhodesJ, Tosolini M, Mouly L, Lehmann M, Toulas C, Cohen-Jonathan Moyal E, MonferranS. RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma. Oncotarget. 2018;9(73):33788-33803.
4: Hardonnière K, Saunier E, Lemarié A, Fernier M, Gallais I, Héliès-Toussaint C, Mograbi B, Antonio S, Bénit P, Rustin P, Janin M, Habarou F, Ottolenghi C, Lavault MT, Benelli C, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D. The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival. Sci Rep. 2016 Aug 4;6:30776.
5: Sesen J, Dahan P, Scotland SJ, Saland E, Dang VT, Lemarié A, Tyler BM, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry JE, Skuli N. Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. PLoS One. 2015;10(4):e0123721.
6: Dahan P, Martinez Gala J, Delmas C, Monferran S, Malric L, Zentkowski D, Lubrano V, Toulas C, Cohen-Jonathan Moyal E, Lemarie A. Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance. Cell Death Dis. 2014;5(11):e1543.
7: Lemarie A, Huc L, Pazarentzos E, Mahul-Mellier AL, Grimm S. Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction. Cell Death Differ. 2011 Feb;18(2):338-49.
8: Lemarie A, Grimm S. Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells. Mitochondrion. 2009 Jul;9(4):254-60.
9: Lemarie A, Grimm S. Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer? Oncogene. 2011 Sep 22;30(38):3985-4003.
10: Lemarie A, Bourdonnay E, Morzadec C, Fardel O, Vernhet L. Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway. J Immunol. 2008 May 1;180(9):6010-7.
Servane works at IRSET – INSERM UMR 1085 in Rennes, in team 3 headed by Dominique Lagadic-Gossman and under the supervision of Laurence Huc. AgroParisTech engineer, she integrated the network HOLIMITOX in 2022 and studies the toxicological and carcinogenic effects of succinate dehydrogenase inhibitor fungicides, particularly in vivo in the liver, and in vitro on human colonic epithelial cells. |
Marc Le Vée is an engineer in the Xenobiotic and Barrier team “XenoBar” at IRSET/UMR Inserm 1085 (University of Rennes1). For 20 years, he has been working on membrane transporters that influence the uptake and elimination of xenobiotics in organs such as the intestine, liver and kidneys. He has studied the effect of pro-inflammatory cytokines on the expression and function of these transporters, demonstrating their potential impact on drug pharmacokinetics (work cited by the Food and Drug Agency “FDA”). For several years, the team has also been interested in the interaction of environmental contaminants with these transporters and has notably demonstrated the interaction of extracts of diesel particles with membrane transporters in the liver (work cited by INSERM). At present, the team contributes strongly to the determination of potential interactions between emerging pollutants and transporters of xenobiotics but also of endogenous compounds (bile acids, hormones, etc…). |
Selected publications
Lefèvre CR, Le Vée M, Gaubert S, Jouan E, Bruyere A, Moreau C, Fardel O. Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity. Int J Mol Sci. 2021 Nov 29;22(23):12926. doi: 10.3390/ijms222312926.
Le Vée M, Bruyère A, Jouan E, Fardel O. Janus kinase-dependent regulation of drug detoxifying protein expression by interleukin-22 in human hepatic cells. Int Immunopharmacol. 2020 Jun;83:106439. doi: 10.1016/j.intimp.2020.106439. Epub 2020 Mar 29.PMID: 32234672
Guéniche N, Bruyere A, Le Vée M, Fardel O. Implication of human drug transporters to toxicokinetics and toxicity of pesticides. Pest Manag Sci. 2020 Jan;76(1):18-25. doi: 10.1002/ps.5577. Epub 2019 Sep 10.PMID: 31392818 Review.
Le Vée M, Bacle A, Bruyere A, Fardel O. Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379. doi: 10.1002/jbt.22379. Epub 2019 Jul 31.PMID: 31364238
Le Vée M, Bacle A, Jouan E, Lecureur V, Potin S, Fardel O. Induction of multidrug resistance-associated protein 3 expression by diesel exhaust particle extract in human bronchial epithelial BEAS-2B cells. Toxicol In Vitro. 2019 Aug;58:60-68. doi: 10.1016/j.tiv.2019.03.021. Epub 2019 Mar 19.PMID: 30898553
Mayati A, Moreau A, Le Vée M, Bruyère A, Jouan E, Denizot C, Parmentier Y, Fardel O. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018 Oct 31;8(1):16115. doi: 10.1038/s41598-018-34421-8.PMID: 30382126
Sayyed K, Camillerapp C, Le Vée M, Bruyère A, Nies AT, Abdel-Razzak Z, Fardel O. Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines. Toxicol In Vitro. 2019 Feb;54:10-22. doi: 10.1016/j.tiv.2018.08.015. Epub 2018 Sep 3.PMID: 30189235
Sayyed K, Le Vée M, Chamieh H, Fardel O, Abdel-Razzak Z. Cigarette smoke condensate alters Saccharomyces cerevisiae efflux transporter mRNA and activity and increases caffeine toxicity. Toxicology. 2018 Nov 1;409:129-136. doi: 10.1016/j.tox.2018.08.005. Epub 2018 Aug 15.PMID: 30118793
Le Vee M, Jouan E, Stieger B, Lecureur V, Fardel O. Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract. PLoS One. 2015 Mar 24;10(3):e0121232. doi: 10.1371/journal.pone.0121232. eCollection 2015.PMID: 25803276
Le Vee M, Lecureur V, Stieger B, Fardel O. Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6. Drug Metab Dispos. 2009 Mar;37(3):685-93. doi: 10.1124/dmd.108.023630. Epub 2008 Dec 15.PMID: 19074973
Cécile Ménez is a Research Fellow at the UMR 1436 INRAE/ENVT laboratory “Therapeutic innovations and resistance” in Toulouse. Since 2008, she has been working on the adaptive mechanisms and the identification of selected targets at the genomic and transcriptomic level during the adaptation and the acquisition of resistance in organisms in response to exposure to xenobiotics and more particularly to antiparasitic drugs. She uses the C. elegans model to analyze the fingerprints of a xenobiotic exposure in order to have a predictive system of a toxic exposure and to understand the mechanisms of adaptation of pathogens to drugs. C. Ménez is a member of the GENIE consortium as principal investigator on the C. elegans model. |
Selected publications
Long, M. Alberich, F. André, C. Ménez, Roger K. Prichard, A. Lespine. The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF‑12. Science Reports. 2020 Jul 8;10(1):11207. doi: 10.1038/s41598-020-67466-9.
Ménez C, Alberich M, Courtot E, Guegnard F, Blanchard A, Aguilaniu H, Lespine A. The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes. PLoS Pathogens. 2019 Feb 13;15(2):e1007598. doi: 10.1371/journal.ppat.1007598
Ménez C, Albérich M, Kansoh, Blanchard A, Lespine A. Acquired tolerance to ivermectin and moxidectin after drug selection pressure in the nematode Caenorhabditis elegans. Antimicrobial Agents and Chemotherapy. 2016. 60(8), 4809-4819. doi:AAC.00713-16 [pii] 10.1128/AAC.00713-16
Kotze AC, Hunt PW, Philip Skuce P, von Samson Himmelstjerna G, Martin RJ, Sager H, Krucken J, Hodgkinson J, Lespine A, Jex AR Gilleard JS, Beech RN, Wolstenholme AJ, Demeler J, Robertson, Charvet C, Neveu C, Kaminsky R, Rufener L, Alberich M, Ménez C, Prichard RK. Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug / receptor interactions. International Journal for Parasitology – Drugs and Drug Resistance. 2014. 4, 164-184. Doi:10.1016/j.ijpddr.2014.07.007
Camille Pasquet defended a thesis in environmental chemistry (“Bioavailability estimation of nickel, cobalt and manganese in dust from ultramafic soils and development of a bioindication tool using lichen for dust emitted by mining activities in New Caledonia”). Her research focuses on the impact of human activities on the environment. Since 2021, she is a post-doctoral researcher at the CNRS-Centre de Biophysique Moléculaire in the team “Pesticides: Environment, Biodiversity and Health “directed by Jean-Marc Bonmatin. She is currently working on the development of analytical methods to quantify SDHI fungicides’ exposure in food. |
Selected publications
Utilisation of an enzyme-linked immunosorbent assay (ELISA) for determination of alkylphenols in various environmental matrices. Comparison with LC-MS/MS method. Pasquet, C.; Vulliet E. (2011) Talanta 85(5) p 2492-2497
Mobility of Ni, Co, and Mn in ultramafic mining soils of New Caledonia, assessed by kinetic EDTA extractions. Pasquet, C.; Monna, F.; van Oort, F.; Gunkel-Grillon, P.; Laporte-Magoni, C.; Losno, R.; Château, C. (2018) Environmental Monitoring and Assessment 190, 638
Christophe Roux is professor at the University Toulouse III-Paul Sabatier, member of the Research Laboratory in Plant Sciences (LRSV – CNRS / UT3 / INPT). He is head of the team “Microbial Interactions in the Rhizosphere and Roots ” and scientific co-leader of the joint laboratory BioPlantProducts. His group works on plant microbiota, and aims at developping new strategies for sustainable agricultural practices. Christophe Roux is expert in the biology of arbuscular mycorrhizal fungi, a group of soil fungi which are symbiont of a vast majority of plants. Using approaches in functional genomics and diversity analyses, he works at identifying mechanisms that support the symbiotic efficiency on plant growth. |
Selected publications
Malar C, M., Roux, C. & Corradi, N. (2021). Regulation of mating genes during arbuscular mycorrhizal isolate co-existence—where is the evidence? ISME J
Malar C, M., Krüger, M., Krüger, C., Wang, Y., Stajich, J.E., Keller, J., Chen, E.C.H., Yildirir, G., Villeneuve-Laroche, M., Roux, C., Delaux, P.M. & Corradi, N. (2021). The genome of Geosiphon pyriformis reveals ancestral traits linked to the emergence of the arbuscular mycorrhizal symbiosis, Current Biology, https://doi.org/10.1016/j.cub.2021.01.058.
Simons, A., Bertron, A., Aubert, J. E., Roux, C., & Roques, C. (2020). Characterization of the microbiome associated with in situ earthen materials. Environmental Microbiome, 15(1), 1-11.
Mathieu, S.*, Cusant, L*., Roux, C., & Corradi, N. (2018). Arbuscular mycorrhizal fungi: intraspecific diversity and pangenomes. New Phytologist. 220(4), 1129-1134.
Pierart, A., Dumat, C., Maes, A. Q., Roux, C., & Sejalon-Delmas, N. (2018). Opportunities and risks of biofertilization for leek production in urban areas: Influence on both fungal diversity and human bioaccessibility of inorganic pollutants. Science of The Total Environment, 624, 1140-1151.
Chen E, Morin E, Beaudet D, Noel J, Yildirir G, Ndikumana S, Charron P, Stonge C, Giorgi J, Kruger M, Marton T, Ropars J, Grigoriev IV, Hainaut M, Henrissat B, Roux C, Martin F & Corradi N (2018) High intraspecific genome diversity in the model arbuscular mycorrhizal symbiont Rhizophagus irregularis. New Phytologist, 220(4), 1161-1171
Tang N, San Clemente H, Roy S, Bécard G, Zhao B, Roux C. 2016. A Survey of the Gene Repertoire of Gigaspora rosea Unravels Conserved Features among Glomeromycota for Obligate Biotrophy. Frontiers in Microbiology 7: 1–16.
Besserer, A., G. Becard, A. Jauneau, C. Roux and N. Sejalon-Delmas (2008). “GR24, a Synthetic Analog of Strigolactones, Stimulates the Mitosis and Growth of the Arbuscular Mycorrhizal Fungus Gigaspora rosea by Boosting Its Energy Metabolism.” Plant Physiol. 148 (1): 402-413.
Besserer A., V. Puech-Pagès, P. Kiefer, V. Gomez-Roldan, A. Jauneau, S. Roy, J-C Portais, C. Roux, G. Bécard and N. Séjalon-Delmas (2006). Strigolactones Stimulate Arbuscular Mycorrhizal Fungi by Activating Mitochondria PLoS Biology Vol. 4, No. 7, e226
Joost Schanstra is heading the team “Biomarkers, mechanisms and complications of kidney disease” of INSERM-U1297 (I2MC, Toulouse) and brings a 20 year-long expertise in mechanisms and biomarkers of kidney disease (key papers in JCI 1998, 2002, JASN 2010, KI 2007, 2016, Nat Med 2006 and Science Transl Med 2013). Joost Schanstra has published >170 publications cited 6000 times, has a Hirsch factor of 42 (WoS) and is the main applicant in 2 patents.
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Sélécted publications
Schanstra JP, Luong T, Makridakis M, Van Linthout S, Lygirou V, Latosinska A, Alesutan I, Boehme B, Schelski N, Von Lewinski D, Mullen W, Nicklin S, Delles C, Feuillet G, Denis C, Lang F, Pieske B, Bascands JL, Mischak H, Saulnier-Blache JS, Voelkl J, Vlahou A, Klein J. Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment. JCI Insight. 2019 May 16;4(10).
Klein J, Ramirez-Torres A, Ericsson A, Huang Y, Breuil B, Siwy J, Mischak H, Peng XR, Bascands JL, Schanstra JP. Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice. Kidney Int. 2016 Nov;90(5):1045-1055.
Schanstra JP, Zürbig P, Alkhalaf A, Argiles A, Bakker SJL, Beige J, Bilo HJG, Chatzikyrkou C, Dakna M, Dawson J, Delles C, Haller H, Haubitz M, Husi H, Jankowski J, Jerums J, Kleefstra N, Kuznetsova T, Maahs DM, Menne J, Mullen W, Ortiz A, Persson F, Rossing P, Ruggenenti P, Rychlik I, Serra AL, Siwy J, Snell-Bergeon J, Spasovski G, Staessen JA, Vlahou A, Mischak H, Vanholder R. Diagnosis and prediction of progression of chronic kidney disease by assessment of urinary peptides. J Am Soc Nephrol. 2015 Aug;26(8):1999-2010.
Klein J, Lacroix C, Caubet C, Siwy J, Zürbig P, Dakna M, Muller F, Breuil B, Stalmach A, Mullen W, Mischak H, Bandin F, Monsarrat B, Bascands JL, Decramer S, Schanstra JP. Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves (PUV). Science Transl Med. 2013, Aug 14;5(198):198ra106.
Decramer S, Wittke S, Mischak H, Zurbig P, Walden M, Bouissou F, Bascands JL, Schanstra JP. Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis. Nat Med. 2006, 12, 398-400.
Mireille Sebbag est CRCN à l’Inserm et possède une expertise dans les maladies inflammatoires chroniques rhumatologiques ou digestives. Elle a longuement travaillé sur des autoanticorps associés à la polyarthrite rhumatoïde et notamment participé au développement de tests pour son diagnostic. Elle a récemment rejoint l’équipe Physiopathologie de l’Épithélium Intestinal de l’Institut de Recherche en Santé Digestive (IRSD, INRAE U1416-Inserm U1220, Toulouse, France) qui consacre une grande partie de ses recherches à la manière par laquelle des dérèglements de la physiologie des cellules épithéliales intestinales peuvent contribuer à des maladies digestives telles que les maladies inflammatoires chroniques de l’intestin, le syndrôme du côlon irritable ou encore le cancer colorectal, avec un focus sur les acteurs l’homéostasie protéolytique. Elle utilise notamment des modèles basés sur la culture primaire de cellules épithéliales coliques sous forme d’organoïdes. |
Principales publications